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Fluvastin therapy affects TAFI concentration in kidney transplant recipients.
- Source :
-
Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2003 Jan; Vol. 16 (1), pp. 53-7. Date of Electronic Publication: 2002 Dec 10. - Publication Year :
- 2003
-
Abstract
- Thrombin activatable fibrinolysis inhibitor (TAFI) is a glycoprotein, linking coagulation and fibrinolysis. Recently, attention has been drawn to the beneficial effects of statins on haemostasis in kidney patients prone to dyslipidaemia and with a high risk of cardiovascular death. The purpose of this study was to assess whether fluvastatin affects TAFI concentration in renal transplant recipients. We evaluated thrombin-antithrombin (TAT) complexes, prothrombin fragments 1+2, thrombomodulin, plasmin-antiplasmin (PAP) complexes, TAFI, P-selectin, and lipoprotein (a), 1, 2, and 3 months before and after fluvastatin treatment and in normolipaemic kidney transplant recipients and healthy volunteers. Cholesterol and LDL fell significantly as soon as 1 month after treatment had begun and remained lowered during the therapy. TAFI and prothrombin fragments 1+2 decreased significantly after 3 months of fluvastatin administration, whereas P-selectin decreased significantly after 2 months and remained significantly lower after 3 months of this therapy. We can conclude that fluvastatin is an effective hypolipaemic agent that favourably affects haemostasis.
- Subjects :
- Adult
Antithrombin III
Female
Fibrinolysin metabolism
Fluvastatin
Hemostasis drug effects
Humans
Hyperlipidemias blood
Lipids blood
Male
Middle Aged
P-Selectin blood
Peptide Fragments blood
Peptide Hydrolases blood
Protein Precursors blood
Prothrombin
Carboxypeptidase B2 blood
Fatty Acids, Monounsaturated administration & dosage
Hydroxymethylglutaryl-CoA Reductase Inhibitors administration & dosage
Hyperlipidemias drug therapy
Indoles administration & dosage
Kidney Transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 0934-0874
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Transplant international : official journal of the European Society for Organ Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 12545342
- Full Text :
- https://doi.org/10.1007/s00147-002-0495-9