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Comparison of the effect of various antisera and cobra venom factor on inflammatory reactions in guinea-pig skin. II. The Arthus reaction and the local Shwartzman reaction.
- Source :
-
The Journal of pathology [J Pathol] 1975 Feb; Vol. 115 (2), pp. 111-25. - Publication Year :
- 1975
-
Abstract
- The ability of antisera to guinea-pig C3 to inhibit the Arthus and local Shwartzman reactions was studied. They were found to reduce the non-haemorrhagic component of the active and reversed passive Arthus reactions and to delay the appearance of the haemorrhage in the active Arthus reaction. Cobra venom factor, however, had no effect on the non-haemorrhagic components of these reactions and only delayed the appearance of the haemorrhage of the active Arthus reaction. There appeared to be a correlation between the serum complement level and the time taken for the haemorrhage to appear, and between the circulating platelet count and the extent of the non-haemorrhagic, oedematous component of the reaction. The haemorrhagic component of the local Shwartzman reaction was not affected by decomplementation with cobra venom factor. The ability of the antisera to inhibit the haemorrhage of the Shwartzman reaction was not dependent on lowering the serum complement titre. However, the haemorrhage was inhibited if the circulating platelet count was also reduced to very low numbers. Antiserum to zymosan alone had the same effect as anti-beta1C/beta1A globulin (zymosan) in blocking the reaction, although it did not alter the complement levels or the platelet counts. The possibility of an immunological cross-reactivity between zymosan and endotoxin in this action is discussed.
- Subjects :
- Animals
Antibodies
Arthus Reaction pathology
Blood Platelets analysis
Complement C3 analysis
Complement System Proteins analysis
Cross Reactions
Endotoxins immunology
Escherichia coli immunology
Guinea Pigs
Hemorrhage prevention & control
Lipopolysaccharides immunology
Male
Ovalbumin immunology
Skin immunology
Zymosan immunology
Arthus Reaction immunology
Immune Sera
Inflammation
Shwartzman Phenomenon immunology
Snake Venoms
Venoms
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3417
- Volume :
- 115
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 125318
- Full Text :
- https://doi.org/10.1002/path.1711150207