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Diabetes mellitus and 2,3,7,8-tetrachlorodibenzo-p-dioxin elimination in veterans of Operation Ranch Hand.

Authors :
Michalek JE
Ketchum NS
Tripathi RC
Source :
Journal of toxicology and environmental health. Part A [J Toxicol Environ Health A] 2003 Feb 14; Vol. 66 (3), pp. 211-21.
Publication Year :
2003

Abstract

Using multivariate statistical models, no significant relationship was found between the rate of 2,3,7,8-tetrachlorodibenzo-p-dioxin ( TCDD) elimination and the occurrence or time to onset of diabetes in 343 veterans of Operation Ranch Hand, the unit responsible for the aerial spraying of Agent Orange and other TCDD-contaminated herbicides during the Vietnam War. Without adjustment for age, body mass index, family history of diabetes, and smoking history, the time to onset of diabetes decreased and the risk of diabetes increased with a diminished elimination rate. However, after adjustment, diabetes time to onset and occurrence were not significantly associated with TCDD elimination. Analyses of covariance found no significant difference between the average elimination rates of diabetic and nondiabetic veterans, without or with adjustment for risk factors. To our knowledge, this is the only study to date to examine TCDD elimination and diabetes.

Details

Language :
English
ISSN :
1528-7394
Volume :
66
Issue :
3
Database :
MEDLINE
Journal :
Journal of toxicology and environmental health. Part A
Publication Type :
Academic Journal
Accession number :
12521668
Full Text :
https://doi.org/10.1080/15287390306373