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Prognostic value of cell proliferation markers, tumour suppressor proteins and cell adhesion molecules in primary squamous cell carcinoma of the larynx and hypopharynx.
- Source :
-
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2003 Jan; Vol. 260 (1), pp. 28-34. Date of Electronic Publication: 2002 Jul 24. - Publication Year :
- 2003
-
Abstract
- In an attempt to identify molecular prognostic markers, a series of laryngeal and hypopharyngeal carcinomas was examined for PCNA, Ki67, p27(Kip1), p53, E-cadherin and CD44 by immunohistochemistry and for DNA content by flow cytometry. No correlation was found between E-cadherin, CD44, p53 or DNA ploidy and the clinicopathological data. The fraction of cancer cells immunolabelled for p27(Kip1) correlated with tumour differentiation, but not with lymph node metastasis. In contrast, the PCNA, Ki67 and S-phase fractions of cancer cells were significantly higher in tumours with lymph node metastasis than in those without lymph node metastasis and were correlated with pathological T-stages and with tumour dedifferentiation. In univariate analysis, advanced pathological T-stage, lymph node metastasis and high fractions of cancer cells immunolabelled for PCNA or Ki67 inversely correlated with overall and disease-free survival. In multivariate analysis, lymph node metastasis was the only factor significantly associated with poor survival. The data suggest that immunohistochemical investigation of PCNA and Ki67 and flow cytometric analysis of S-phase fractions may be useful predictive markers of biological aggressiveness in laryngeal carcinomas.
- Subjects :
- Aged
Cadherins immunology
Carcinoma, Squamous Cell immunology
Cell Cycle Proteins immunology
Cyclin-Dependent Kinase Inhibitor p27
Female
Flow Cytometry instrumentation
Genetic Markers
Humans
Hyaluronan Receptors immunology
Hypopharyngeal Neoplasms immunology
Immunoglobulin G immunology
Immunohistochemistry
Ki-67 Antigen immunology
Laryngeal Neoplasms immunology
Male
Middle Aged
Ploidies
Predictive Value of Tests
Prognosis
Proliferating Cell Nuclear Antigen immunology
Tumor Suppressor Protein p53 immunology
Tumor Suppressor Proteins immunology
Cadherins genetics
Carcinoma, Squamous Cell genetics
Carcinoma, Squamous Cell pathology
Cell Cycle Proteins genetics
Hyaluronan Receptors genetics
Hypopharyngeal Neoplasms genetics
Hypopharyngeal Neoplasms pathology
Ki-67 Antigen genetics
Laryngeal Neoplasms genetics
Laryngeal Neoplasms pathology
Proliferating Cell Nuclear Antigen genetics
Tumor Suppressor Protein p53 genetics
Tumor Suppressor Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0937-4477
- Volume :
- 260
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 12520353
- Full Text :
- https://doi.org/10.1007/s00405-002-0512-8