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[Myocardial and coronary vessel dysfunction in diabetes I patients].
- Source :
-
Przeglad lekarski [Przegl Lek] 2002; Vol. 59 (7), pp. 514-8. - Publication Year :
- 2002
-
Abstract
- Despite of dramatic improvement in diagnostic procedures and treatment of diabetic patients, cardio-vascular complications are still the most frequent causes of death in these patients. Diabetes influences myocardial and coronary vessels function by coexisting macroangiopathy, microangiopathy, metabolic disturbances and autonomic nervous system neuropathy. All these factors result in diastolic and systolic dysfunction of the heart. Cardiomyopathy, congestive heart failure and serious arrhythmias are the end stage of diabetic complications. Macroangiopathy demonstrates accelerated atherosclerosis (involving coronary arteries), which consequences can be observed in 1 type diabetes patients at around the age of 30. Causes of increased risk of macroangiopathy in type 1 diabetic patients are not clear. There are not many clinical, prospective trials which can allow for etiology determination of the increased incidence of atherosclerosis and mortality due to coronary artery disease in this population. Adding to traditional risk factors of atherosclerosis like genetic factors, hypertension, dyslipidemia, obesity, smoking and improper diet, other important risk factors are observed in diabetic patients. Only few clinical trials suggest that hyperglycemia, glycation, glycoxidation of proteins, lipoproteins, changes in their composition, microalbuminuria, coagulation, fibrinolytic disturbances are additional risk factors of endothelium dysfunction and atherosclerosis. Prevention and treatment of accelerated coronary artery disease and it's consequences are more complicated in the diabetic population than in others. Some of the clinical trials suggest that even improved glycemic control does not eliminate the elevated risk of coronary artery disease in type 1 diabetic patients.
- Subjects :
- Arrhythmias, Cardiac etiology
Cardiomyopathies physiopathology
Cardiomyopathy, Dilated etiology
Coronary Artery Disease etiology
Diabetic Angiopathies complications
Diabetic Angiopathies physiopathology
Heart Failure physiopathology
Humans
Risk Factors
Cardiomyopathies etiology
Coronary Vessels physiopathology
Diabetes Mellitus, Type 1 complications
Diabetic Angiopathies etiology
Heart Failure etiology
Subjects
Details
- Language :
- Polish
- ISSN :
- 0033-2240
- Volume :
- 59
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Przeglad lekarski
- Publication Type :
- Academic Journal
- Accession number :
- 12516240