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Atrial natriuretic peptide stimulates cat carotid body chemoreceptors in vivo.
- Source :
-
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology [Comp Biochem Physiol A Mol Integr Physiol] 2003 Jan; Vol. 134 (1), pp. 27-31. - Publication Year :
- 2003
-
Abstract
- It is known that atrial natriuretic peptide (ANP) is released from cardiac myocyte and other stores during hypoxia and is involved in pulmonary-cardiovascular reflexes and in natriuresis and diuresis. Since the carotid body initiates hypoxic chemoreflexes, we hypothesized that ANP could potentiate the hypoxic stimulation of the carotid body chemoreceptor in vivo. We studied the effect of close intra-arterial injection of ANP on carotid chemoreceptor activity in anesthetized male cats which were paralyzed and artificially ventilated. Graded doses of ANP (0-10 nmoles) were administered by intra-arterial injections and they produced an excitatory response. Single dose of ANP (6.5 nmoles) at four steady-state levels of arterial PO(2), at constant PCO(2), produced increases of chemoreceptor activity. This increase of chemoreceptor activity with ANP in the presence of CO(2)-HCO(3)(-) in vitro could make a difference from those without CO(2)-HCO(3)(-) in vivo.
- Subjects :
- Adaptation, Physiological physiology
Animals
Carbon Dioxide blood
Cats
Chemoreceptor Cells drug effects
Chemoreceptor Cells physiology
Dose-Response Relationship, Drug
Hypoxia metabolism
Male
Oxygen blood
Atrial Natriuretic Factor pharmacology
Carotid Body drug effects
Carotid Body physiology
Hypoxia physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-6433
- Volume :
- 134
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
- Publication Type :
- Academic Journal
- Accession number :
- 12507604
- Full Text :
- https://doi.org/10.1016/s1095-6433(02)00145-9