[The effect of the synthetic analogue of gonadoliberin on immune response and factors of nonspecific resistance in rats and mice].

Authors :: Bobyntsev II
Sever'ianova LA
Konoplia AI
Smakhtin MIu
Kriukov AA
Source :: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova [Ross Fiziol Zh Im I M Sechenova] 2002 Sep; Vol. 88 (9), pp. 1177-81.
Publication Year :: 2002
Abstract: Gonadotropin-releasing hormone's synthetic analogue (surfagon) injected intraperitoneally exerted a dose-dependent influence on humoral immune response values in rats and on phagocytic and functional activity of neutrophiles in mice. Castration induced a reliable decrease of the immune response and character. It may be concluded that the surfagon effect is not mediated by steroids.

Subjects :: Animals
Dose-Response Relationship, Drug
Injections, Intraperitoneal
Male
Mice
Orchiectomy
Organ Size drug effects
Phagocytosis drug effects
Phagocytosis physiology
Rats
Rats, Wistar
Spleen drug effects
Spleen immunology
Gonadotropin-Releasing Hormone analogs & derivatives
Gonadotropin-Releasing Hormone pharmacology
Hormones pharmacology
Immunity, Innate drug effects
Neutrophils physiology

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