Capsule switching among C:2b:P1.2,5 meningococcal epidemic strains after mass immunization campaign, Spain.

Authors :: Alcalá B
Arreaza L
Salcedo C
Uría MJ
De La Fuente L
Vázquez JA
Source :: Emerging infectious diseases [Emerg Infect Dis] 2002 Dec; Vol. 8 (12), pp. 1512-4.
Publication Year :: 2002
Abstract: A mass immunization campaign for 18-month to 19-year-olds was undertaken in Spain in 1996-1997 because of an epidemic of serogroup C meningococcal disease associated with a C:2b:P1.2,5 strain belonging to the A4 lineage. Surveillance for the "capsule-switching" phenomenon producing B:2b:P1.2,5 isolates was undertaken. Of 2,975 meningococci characterized, B:2b:P1.2,5 and B:2b:P1.2 antigenic combinations were found in 18 isolates; 15 meningococci were defined as serogroup B belonging to the A4 lineage.

Subjects :: Adolescent
Adult
Child
Child, Preschool
Electrophoresis, Gel, Pulsed-Field
Humans
Infant
Meningitis, Meningococcal prevention & control
Polysaccharides, Bacterial administration & dosage
Polysaccharides, Bacterial isolation & purification
Spain epidemiology
Bacterial Capsules classification
Mass Vaccination statistics & numerical data
Meningitis, Meningococcal epidemiology
Polysaccharides, Bacterial classification

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