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Leptospira interrogans binds to the CR3 receptor on mammalian cells.
- Source :
-
Microbial pathogenesis [Microb Pathog] 2002 Dec; Vol. 33 (6), pp. 299-305. - Publication Year :
- 2002
-
Abstract
- Pathogenic leptospires adhere to phagocytes even in the absence of specific antibodies; we demonstrate that the CR3 integrin (known as Mac-1 or CD11b/CD18 receptor), expressed on neutrophils and CHO Mac-1 transfected cells, recognizes and binds leptospires. The I-domain of the molecule seems to be involved in the recognition and data suggest that this occurs via fibronectin absorbed at the Leptospira surface. On the other hand, since N-acetyl-D-glucosamine does not behave as antagonist of the binding, the lectin-like domain of the receptor is not involved in the recognition.
Details
- Language :
- English
- ISSN :
- 0882-4010
- Volume :
- 33
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Microbial pathogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 12495676
- Full Text :
- https://doi.org/10.1006/mpat.2002.0537