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The cellular compatibility of five endodontic sealers during the setting period.
- Source :
-
Journal of endodontics [J Endod] 2002 Nov; Vol. 28 (11), pp. 784-6. - Publication Year :
- 2002
-
Abstract
- The purpose of this study was to evaluate the cellular compatibility of five endodontic sealers in the first 24 h after mixing. Specimens of N2, Endomethasone, Apexit, AH Plus, and Ketac Endo were extracted with cell culture medium 0, 1, 5, and 24 h after mixing. Eluates were tested for cytotoxicity with immortal 3T3 cells and primary human periodontal ligament fibroblasts using XTT-assays. Data were analyzed for statistically significant differences by means of Dunnett's t tests (p < 0.05). All extracts of N2 completely inhibited cell metabolism (p < 0.05). Similar effects were provoked by the first three eluates of Endomethasone, but the 24-h extract irritated cells significantly less (p < 0.05). Severe cytotoxicity was also observed with all Ketac Endo extracts (p < 0.05). A significant inhibition of mitochondrial activity was induced by the first (3T3) or the first and second eluate (periodontal ligament fibroblasts) of AH Plus (p < 0.05). The subsequent eluates of this sealer and all extracts of Apexit did not reveal any cytotoxic potency.
- Subjects :
- 3T3 Cells
Animals
Anti-Inflammatory Agents toxicity
Biocompatible Materials chemistry
Calcium Hydroxide toxicity
Dexamethasone toxicity
Drug Combinations
Epoxy Resins toxicity
Eugenol toxicity
Fibroblasts drug effects
Formaldehyde toxicity
Glass Ionomer Cements toxicity
Humans
Indicators and Reagents
Irritants toxicity
Mice
Periodontal Ligament cytology
Periodontal Ligament drug effects
Root Canal Filling Materials chemistry
Statistics as Topic
Tetrazolium Salts
Thymol toxicity
Time Factors
Zinc Oxide toxicity
Administration, Topical
Biocompatible Materials toxicity
Hydrocortisone
Root Canal Filling Materials toxicity
Thymol analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0099-2399
- Volume :
- 28
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of endodontics
- Publication Type :
- Academic Journal
- Accession number :
- 12470025
- Full Text :
- https://doi.org/10.1097/00004770-200211000-00009