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Thymidylate synthase and dihydropyrimidine dehydrogenase expression in oral squamous cell carcinoma: an immunohistochemical and clinicopathologic study.
- Source :
-
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics [Oral Surg Oral Med Oral Pathol Oral Radiol Endod] 2002 Dec; Vol. 94 (6), pp. 717-23. - Publication Year :
- 2002
-
Abstract
- Objective: Thymidylate synthase (TS) is the target enzyme for 5-fluorouracil (5-FU), and dihydropyrimidine dehydrogenase (DPD) is the first enzyme that metabolizes 5-fluorouracil. Until now, only the enzyme activities of TS and DPD have been investigated; however, there are few reports about the immunohistochemistry of TS and DPD and none regarding oral carcinoma. The purpose of this article was to investigate the expression of TS and DPD in oral squamous cell carcinoma.<br />Study Design: In this study, 109 oral squamous cell carcinomas were investigated for the immunohistochemical expression of TS and DPD proteins.<br />Results: The expressions of TS in carcinoma cases was significantly higher than in controls (P <.05, t test). DPD was expressed both in carcinomas and in areas adjacent to the carcinomas. There was no correlation between the clinical factors and the TS labeling index or between the clinical factors and the DPD labeling index (DPD-LI). Pathologically, DPD-LI was significantly different in both the World Health Organization classification and Anneroth's classification. The TS labeling index was significantly correlated with the Ki-67 LI (P <.05, Pearson's correlation coefficient). Although TS showed no correlation between tegafur-uracil response and TS labeling index, there was a significant correlation between the tegafur-uracil response and DPD-LI.<br />Conclusions: TS may reveal tumor cell proliferation, but DPD-LI may correlate with a response to anticancer drug treatment.
- Subjects :
- Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Carcinoma, Squamous Cell drug therapy
Carcinoma, Squamous Cell pathology
Case-Control Studies
Dihydrouracil Dehydrogenase (NADP)
Female
Humans
Immunoenzyme Techniques
Ki-67 Antigen analysis
Male
Middle Aged
Mouth Neoplasms drug therapy
Mouth Neoplasms pathology
Neoplasm Staging
Tegafur administration & dosage
Uracil administration & dosage
Carcinoma, Squamous Cell enzymology
Mouth Neoplasms enzymology
Oxidoreductases biosynthesis
Thymidylate Synthase biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1079-2104
- Volume :
- 94
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
- Publication Type :
- Academic Journal
- Accession number :
- 12464897
- Full Text :
- https://doi.org/10.1067/moe.2002.126912