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Growth hormone therapy.
- Source :
-
Best practice & research. Clinical endocrinology & metabolism [Best Pract Res Clin Endocrinol Metab] 2002 Sep; Vol. 16 (3), pp. 483-503. - Publication Year :
- 2002
-
Abstract
- Since 1958 growth hormone (GH) has been used as substitution treatment for children with GH deficiency. At present, it is clear that a dose of 0.23 mg/kg/week can lead to a final height close to target height, but in view of the wide inter-individual variation, alternative regimens based on invidualizing the dosage with the help of prediction models are being investigated. The best strategy during puberty (increase the dosage, delay puberty) is still uncertain. The value of GH in idiopathic short stature is still heavily debated, although the average final height gain on 0.33 mg/kg/week is 5-7 cm. GH is efficacious in short stature due to chronic renal failure and Prader-Willi syndrome. In other conditions insufficient data are available. There are few side-effects.
- Subjects :
- Body Height drug effects
Dose-Response Relationship, Drug
Drug Administration Schedule
Fetal Growth Retardation complications
Growth Disorders etiology
Growth Hormone administration & dosage
Humans
Metabolism, Inborn Errors drug therapy
Metabolism, Inborn Errors pathology
Metabolism, Inborn Errors physiopathology
Puberty
Growth Disorders drug therapy
Growth Hormone deficiency
Growth Hormone therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1521-690X
- Volume :
- 16
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Best practice & research. Clinical endocrinology & metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 12464230
- Full Text :
- https://doi.org/10.1053/beem.2002.0206