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Reduced severity of HSV-1-induced corneal scarring in IL-12-deficient mice.
- Source :
-
Virus research [Virus Res] 2002 Dec; Vol. 90 (1-2), pp. 317-26. - Publication Year :
- 2002
-
Abstract
- Evidence suggests that in BALB/c mice infected with HSV-1, increased corneal scarring correlated with the presence of IL-12p40 mRNA in the cornea. To determine if this observed correlation reflected function, we have utilized mice with a homologous disruption of the gene encoding either the IL-12p35 subunit or the IL-12p40 subunit of IL-12. The severity of corneal scarring following ocular infection with HSV-1 was reduced significantly in nai;ve IL-12p35- and IL-12p40-deficient mice compared with nai;ve BALB/c mice, with the corneal scarring being low grade in the IL-12p35-deficient mice and completely absent in the IL-12p40-deficient mice. The reduction in the corneal scarring could not be attributed to a reduction in the HSV-1 titers in the eyes, which were not significantly different from the BALB/c mice, or to differences in the production of T(H)1 responses (IL-2 and IFN-gamma production) by the infected mice. Taken together, these results suggest the importance of IL-12 in the induction of corneal scarring in HSV-1-infected mice.
- Subjects :
- Animals
Blepharitis mortality
Blepharitis pathology
Blepharitis virology
Cornea immunology
Cornea virology
Cytokines biosynthesis
Female
Interleukin-12 genetics
Keratitis, Herpetic mortality
Keratitis, Herpetic pathology
Keratitis, Herpetic physiopathology
Keratitis, Herpetic virology
Mice
Mice, Inbred BALB C
Rabbits
Blepharitis physiopathology
Cornea pathology
Herpesvirus 1, Human pathogenicity
Interleukin-12 deficiency
Severity of Illness Index
Subjects
Details
- Language :
- English
- ISSN :
- 0168-1702
- Volume :
- 90
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Virus research
- Publication Type :
- Academic Journal
- Accession number :
- 12457985
- Full Text :
- https://doi.org/10.1016/s0168-1702(02)00249-6