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Sex-related bias and exclusion mapping of the nonrecombinant portion of chromosome Y in human type 1 diabetes in the isolated founder population of Sardinia.
- Source :
-
Diabetes [Diabetes] 2002 Dec; Vol. 51 (12), pp. 3573-6. - Publication Year :
- 2002
-
Abstract
- A male excess in Sardinian type 1 diabetic cases has previously been reported and was largely restricted to those patients carrying the HLA-DR3/nonDR4 genotype. In the present study, we have measured the male- to-female (M:F) ratio in a sample set of 542 newly collected, early-onset type 1 diabetic Sardinian patients. This data not only confirm the excess of male type 1 diabetic patients overall (M:F ratio = 1.3, P = 3.9 x 10(-3)) but also that the bias in male incidence is largely confined to patients with the DR3/nonDR4 genotype (M:F ratio = 1.6, P = 2.0 x 10(-4)). These sex effects could be due to a role for allelic variation of the Y chromosome in the susceptibility to type 1 diabetes, but to date this chromosome has not been evaluated in type 1 diabetes. We, therefore, established the frequencies of the various chromosome Y lineages and haplotypes in 325 Sardinian male patients, which included 180 cases with the DR3/nonDR4 genotype, and 366 Sardinian male control subjects. Our results do not support a significant involvement of the Y chromosome in DR3/nonDR4 type 1 diabetic cases nor in early-onset type 1 diabetes as a whole. Other explanations, such as X chromosome-linked inheritance, are thus required for the male bias in incidence in type 1 diabetes in Sardinia.
- Subjects :
- Child
Child, Preschool
Control Groups
Female
Gene Frequency
Genotype
HLA-DR3 Antigen genetics
HLA-DR4 Antigen genetics
Haplotypes
Humans
Incidence
Italy
Male
Sex Distribution
Chromosome Mapping
Diabetes Mellitus, Type 1 epidemiology
Diabetes Mellitus, Type 1 genetics
Founder Effect
Y Chromosome genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0012-1797
- Volume :
- 51
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Diabetes
- Publication Type :
- Academic Journal
- Accession number :
- 12453916
- Full Text :
- https://doi.org/10.2337/diabetes.51.12.3573