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Abciximab readministration.
- Source :
-
Reviews in cardiovascular medicine [Rev Cardiovasc Med] 2002 Spring; Vol. 3 (2), pp. 67-70. - Publication Year :
- 2002
-
Abstract
- The IIb/IIIa receptor inhibitors have been shown to improve outcomes following percutaneous coronary intervention (PCI), particularly by decreasing periprocedural myocardial necrosis. Abciximab has been subject to multiple studies, demonstrating consistent improved early and late outcomes in multiple patient populations, including a mortality advantage in diabetics, but there has been concern about the possibility of anaphylaxis, thrombocytopenia, and reduced clinical efficacy with repeat administration of abciximab. Results of the ReoPro Readministration Registry, a prospective, phase IV, multicenter registry of 500 patients undergoing PCI who were treated with abciximab at least 7 days after a previous treatment with this same drug, support the contention that abciximab readministration is both safe and clinically efficacious and that there is no significant increase in the incidence of thrombocytopenia as compared with historical controls of trials of first abciximab administration. However, profound thrombocytopenia did occur with increased frequency as compared with historical controls, suggesting a shift from mild to profound thrombocytopenia with abciximab readministration.
- Subjects :
- Abciximab
Angioplasty, Balloon, Coronary
Antibodies, Monoclonal administration & dosage
Clinical Trials, Phase IV as Topic
Coronary Disease therapy
Humans
Immunoglobulin Fab Fragments administration & dosage
Platelet Aggregation Inhibitors administration & dosage
Treatment Outcome
Antibodies, Monoclonal adverse effects
Coronary Disease drug therapy
Immunoglobulin Fab Fragments adverse effects
Platelet Aggregation Inhibitors adverse effects
Platelet Glycoprotein GPIIb-IIIa Complex antagonists & inhibitors
Thrombocytopenia chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 1530-6550
- Volume :
- 3
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Reviews in cardiovascular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 12447149