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Minimal hippocampal width relates to plasma homocysteine in community-dwelling older people.
- Source :
-
Age and ageing [Age Ageing] 2002 Nov; Vol. 31 (6), pp. 440-4. - Publication Year :
- 2002
-
Abstract
- Background: The hippocampus is important for memory. Hippocampal atrophy and higher levels of homocysteine may both predict cognitive dysfunction in community-dwelling older people. We tested if higher homocysteine relates to hippocampal thinning in this group.<br />Subjects: 156 community-dwelling volunteers without clinical memory problems.<br />Method: We measured minimal hippocampal widths on magnetic resonance images and homocysteine in plasma.<br />Results: Minimal hippocampal widths related inversely to homocysteine levels.<br />Conclusions: Our results indicate that, even in healthy older people, homocysteine may damage the hippocampus. Reducing homocysteine levels in healthy older people may help to prevent Alzheimer's disease.
Details
- Language :
- English
- ISSN :
- 0002-0729
- Volume :
- 31
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Age and ageing
- Publication Type :
- Academic Journal
- Accession number :
- 12446289
- Full Text :
- https://doi.org/10.1093/ageing/31.6.440