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Different HATS of the ING1 gene family.
- Source :
-
Trends in cell biology [Trends Cell Biol] 2002 Nov; Vol. 12 (11), pp. 532-8. - Publication Year :
- 2002
-
Abstract
- The ING family of proteins are involved in chromatin remodelling, and bind to and affect the activity of histone acetyltransferase, histone deacetylase, and factor acetyltransferase protein complexes. Some family members affect transcription, including the expression of p53-inducible genes such as p21 and Bax, and ING2 induces p53 acetylation on a site implicated in the regulation of p53 activity. ING1 promotes DNA repair and interacts with proliferating cell nuclear antigen, thus linking DNA repair, apoptosis and chromatin remodelling. Here, we summarize what is known about the molecular interactions of ING1 family proteins and, based on these interactions, develop a model to better understand the impact of ING proteins on multiple biological processes.
- Subjects :
- Cell Cycle Proteins
DNA-Binding Proteins
Humans
Inhibitor of Growth Protein 1
Intracellular Signaling Peptides and Proteins
Nuclear Proteins
Tumor Suppressor Proteins
Gene Expression Regulation, Neoplastic physiology
Genes, Tumor Suppressor physiology
Multigene Family physiology
Proteins genetics
Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0962-8924
- Volume :
- 12
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Trends in cell biology
- Publication Type :
- Academic Journal
- Accession number :
- 12446115
- Full Text :
- https://doi.org/10.1016/s0962-8924(02)02391-7