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Anti-nociceptive effects of diazepam binding inhibitor in the central nervous system of rats.
- Source :
-
Brain research [Brain Res] 2002 Nov 29; Vol. 956 (2), pp. 393-7. - Publication Year :
- 2002
-
Abstract
- The present study investigated the effect of diazepam binding inhibitor (DBI) on nociception in the central nervous system of rats. There were dose-dependent increases in hindpaw withdrawal latency (HWL) to noxious thermal and mechanical stimulation after intrathecal injection of 1, 5 or 10 microg of DBI in rats, indicating a DBI-induced anti-nociceptive effect at the spinal levels of rats. Furthermore, it was found that there were no significant influences of intrathecal co-administration of gamma-aminobutyric acid (GABA) on the intrathecal DBI-induced increases in HWLs of rats. Intracerebroventricular administration of 1, 10 or 20 microg of DBI also induced dose-dependent increases in HWL to thermal and mechanical stimulation in rats, suggesting an anti-nociceptive effect of DBI in the brain. Moreover, there were no significant influences of intracerebroventricular co-administration of 2 microg of GABA on the intracerebroventricular DBI-induced increases in HWL of rats. The results of the present study demonstrated that DBI played anti-nociceptive effects in the central nervous system of rats.<br /> (Copyright 2002 Elsevier Science B.V.)
- Subjects :
- Animals
Diazepam Binding Inhibitor administration & dosage
Dose-Response Relationship, Drug
Injections, Intraventricular
Injections, Spinal
Male
Pain Measurement
Rats
Rats, Wistar
Reaction Time
gamma-Aminobutyric Acid administration & dosage
gamma-Aminobutyric Acid physiology
Central Nervous System drug effects
Diazepam Binding Inhibitor pharmacology
Pain drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0006-8993
- Volume :
- 956
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 12445711
- Full Text :
- https://doi.org/10.1016/s0006-8993(02)03613-2