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Production of type I IFN sensitizes macrophages to cell death induced by Listeria monocytogenes.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2002 Dec 01; Vol. 169 (11), pp. 6522-9. - Publication Year :
- 2002
-
Abstract
- Type I IFNs (IFN-alpha/beta) modulate innate immune responses. Here we show activation of transcription factor IFN regulatory factor 3, the synthesis of large amounts of IFN-beta mRNA, and type I IFN signal transduction in macrophages infected with Listeria monocytogenes. Expression of the bacterial virulence protein listeriolysin O was necessary, but not sufficient, for efficient IFN-beta production. Signaling through a pathway involving the type I IFN receptor and Stat1 sensitized macrophages to L. monocytogenes-induced cell death in a manner not requiring inducible NO synthase (nitric oxide synthase 2) or protein kinase R, potential effectors of type I IFN action during microbial infections. The data stress the importance of type I IFN for the course of infections with intracellular bacteria and suggest that factors other than listeriolysin O contribute to macrophage death during Listeria infection.
- Subjects :
- Animals
Base Sequence
Cell Death drug effects
DNA-Binding Proteins metabolism
Heat-Shock Proteins toxicity
Hemolysin Proteins
Interferon Regulatory Factor-3
Interferon-alpha genetics
Interferon-beta genetics
Macrophages drug effects
Macrophages microbiology
Membrane Proteins
Mice
Mice, Knockout
RNA, Messenger biosynthesis
RNA, Messenger genetics
Receptor, Interferon alpha-beta
Receptors, Interferon deficiency
Receptors, Interferon genetics
Signal Transduction
Transcription Factors metabolism
Virulence
Bacterial Toxins
Interferon-alpha biosynthesis
Interferon-beta biosynthesis
Listeria monocytogenes immunology
Listeria monocytogenes pathogenicity
Macrophages immunology
Macrophages pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1767
- Volume :
- 169
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 12444163
- Full Text :
- https://doi.org/10.4049/jimmunol.169.11.6522