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Production of type I IFN sensitizes macrophages to cell death induced by Listeria monocytogenes.

Authors :
Stockinger S
Materna T
Stoiber D
Bayr L
Steinborn R
Kolbe T
Unger H
Chakraborty T
Levy DE
Müller M
Decker T
Source :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2002 Dec 01; Vol. 169 (11), pp. 6522-9.
Publication Year :
2002

Abstract

Type I IFNs (IFN-alpha/beta) modulate innate immune responses. Here we show activation of transcription factor IFN regulatory factor 3, the synthesis of large amounts of IFN-beta mRNA, and type I IFN signal transduction in macrophages infected with Listeria monocytogenes. Expression of the bacterial virulence protein listeriolysin O was necessary, but not sufficient, for efficient IFN-beta production. Signaling through a pathway involving the type I IFN receptor and Stat1 sensitized macrophages to L. monocytogenes-induced cell death in a manner not requiring inducible NO synthase (nitric oxide synthase 2) or protein kinase R, potential effectors of type I IFN action during microbial infections. The data stress the importance of type I IFN for the course of infections with intracellular bacteria and suggest that factors other than listeriolysin O contribute to macrophage death during Listeria infection.

Details

Language :
English
ISSN :
0022-1767
Volume :
169
Issue :
11
Database :
MEDLINE
Journal :
Journal of immunology (Baltimore, Md. : 1950)
Publication Type :
Academic Journal
Accession number :
12444163
Full Text :
https://doi.org/10.4049/jimmunol.169.11.6522