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Elevated hyaluronan concentration without hyaluronidase activation in malignant epithelial ovarian tumors.
- Source :
-
Cancer research [Cancer Res] 2002 Nov 15; Vol. 62 (22), pp. 6410-3. - Publication Year :
- 2002
-
Abstract
- The concentration and histological distribution of hyaluronan, a tumor promoting extracellular matrix polysaccharide, and the activity of hyaluronidase, a potential source of angiogenic hyaluronan oligosaccharides, were analyzed in malignant epithelial (n = 24), borderline (n = 8), benign epithelial (n = 20), functional cyst (n = 21), and normal (n = 5) tissue samples of human ovary. Hyaluronan concentration increased specifically in cancers (P = 0.001), particularly in grade 3 tumors (>49-fold) and in metastases (>89-fold). Hyaluronan staining in the tissues correlated with hyaluronan concentration (P = 0.002). Hyaluronidase activity slightly decreased from semimalignant through low grade to high grade tumors (P = 0.041). Therefore, hyaluronan accumulation, but not hyaluronidase activation, is associated with the aggressiveness of ovarian epithelial cancer.
- Subjects :
- Adult
Aged
Aged, 80 and over
Enzyme Activation
Enzyme-Linked Immunosorbent Assay
Epithelial Cells enzymology
Epithelial Cells metabolism
Epithelial Cells pathology
Female
Humans
Middle Aged
Neoplasm Metastasis
Ovarian Neoplasms enzymology
Ovarian Neoplasms pathology
Staining and Labeling methods
Hyaluronic Acid metabolism
Hyaluronoglucosaminidase metabolism
Ovarian Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0008-5472
- Volume :
- 62
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Cancer research
- Publication Type :
- Academic Journal
- Accession number :
- 12438225