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Induction of regulatory T cells by the immunomodulating cytokines alpha-melanocyte-stimulating hormone and transforming growth factor-beta2.
- Source :
-
Journal of leukocyte biology [J Leukoc Biol] 2002 Nov; Vol. 72 (5), pp. 946-52. - Publication Year :
- 2002
-
Abstract
- Recently, we have reported that the cytokines alpha-melanocyte-stimulating hormone (alpha-MSH) and transforming growth factor-beta2 (TGF-beta2) work in synergy to induce the activation of regulatory T (Treg) cells. When we used alpha-MSH and TGF-beta2 to generate ocular autoantigen-specific Treg cells and adoptively transferred them into mice susceptible to experimental autoimmune uveoretinitis (EAU), there was suppression in the incidence and severity of EAU. Specificity to a retinal autoantigen was required for the Treg cells to suppress EAU. When stimulated, these Treg cells produced TGF-beta1, and their production of interferon-gamma, interleukin (IL)-10, and IL-4 was suppressed. Also, the Treg cells are suppressed in their proliferative response. Our results demonstrate that alpha-MSH with TGF-beta2 induce Treg cells that can subdue a tissue-specific autoimmune response. This also promotes the possibility of using these immunomodulating cytokines to purposely induce antigen-specific Treg cells to prevent and suppress autoimmune disease.
- Subjects :
- Adoptive Transfer
Animals
Autoantigens immunology
Autoimmune Diseases diagnosis
Autoimmune Diseases immunology
CD4-Positive T-Lymphocytes drug effects
CD4-Positive T-Lymphocytes transplantation
Cells, Cultured
Female
Interferon-gamma biosynthesis
Interferon-gamma genetics
Lymphokines biosynthesis
Mice
RNA, Messenger biosynthesis
Retinitis diagnosis
Retinitis immunology
Retinol-Binding Proteins immunology
Transforming Growth Factor beta biosynthesis
Transforming Growth Factor beta genetics
Transforming Growth Factor beta1
Transforming Growth Factor beta2
Uveitis diagnosis
Uveitis immunology
CD4-Positive T-Lymphocytes immunology
Eye Diseases immunology
Eye Proteins
Immunosuppressive Agents pharmacology
Transforming Growth Factor beta pharmacology
alpha-MSH pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0741-5400
- Volume :
- 72
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of leukocyte biology
- Publication Type :
- Academic Journal
- Accession number :
- 12429716