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Bicalutamide monotherapy versus flutamide plus goserelin in prostate cancer: updated results of a multicentric trial.

Authors :
Boccardo F
Barichello M
Battaglia M
Carmignani G
Comeri G
Ferraris V
Lilliu S
Montefiore F
Portoghese F
Cortellini P
Rigatti P
Usai E
Rubagotti A
Source :
European urology [Eur Urol] 2002 Nov; Vol. 42 (5), pp. 481-90.
Publication Year :
2002

Abstract

Objectives: To compare the efficacy of bicalutamide monotherapy to maximal androgen blockade in advanced prostatic cancer.<br />Patients and Methods: Previously untreated patients with histologically proven stage C or D (American Urological Association Staging System) disease were randomly allocated to either bicalutamide (B) or goserelin plus flutamide (G+F). After disease progression, patients treated with B were assigned to castration. The primary endpoint for this trial was overall survival. Prostate cancer-specific survival and progression were included among secondary endpoints.<br />Results: In total 108 patients received B and 112 received G+F. At a median follow-up time of 54 months (range 1-89), 151 patients progressed and 113 died. There was no significant difference in the duration of either progression-free or overall survival. Hazards of progression, death and cancer-specific death, corrected by disease stage, tumor grade and baseline PSA level, showed that patients initially assigned to B had a higher risk of progression but a comparable risk of death and cancer-specific death with the exception of patients with G3 tumors who had an increased risk of death).<br />Conclusions: In patients with well or moderately well differentiated tumors, B monotherapy followed by castration may offer the same survival chance as maximal androgen deprivation. In those patients it thus represents a reasonable choice that can avoid the side effects of androgen deprivation for considerable periods of time.

Details

Language :
English
ISSN :
0302-2838
Volume :
42
Issue :
5
Database :
MEDLINE
Journal :
European urology
Publication Type :
Academic Journal
Accession number :
12429158
Full Text :
https://doi.org/10.1016/s0302-2838(02)00435-9