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Influence of latanoprost on the corneal epithelial barrier function in glaucoma patients.
- Source :
-
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde [Ophthalmologica] 2002 Sep-Oct; Vol. 216 (5), pp. 351-4. - Publication Year :
- 2002
-
Abstract
- Aim: To evaluate the influence of topically administered latanoprost, a prostaglandin F(2alpha) analog, on the corneal epithelial barrier function.<br />Patients and Methods: Twenty-four patients suffering from a glaucoma were enrolled. Ten patients without prior topical antiglaucoma medication received topical latanoprost (0.005%, once daily) for 30 days (monotherapy group); 14 patients receiving topical antiglaucoma medication also received latanoprost (0.005%, once daily) for 180 days (combination treatment group). Before and 30 days after treatment (monotherapy group) and before and 30 and 180 days after treatment (combination group), the corneal epithelial barrier function was measured by a fluorophotometric technique.<br />Results: The fluorescein uptakes in the monotherapy group were 54.6 +/- (SE) 7.5 and 57.1 +/- 11.0 ng/ml before and 30 days after treatment, respectively (p = 0.81). In the combination group, the uptakes were 101.0 +/- 18.3 and 118.9 +/- 25.9 ng/ml (p = 0.38) and 93.4 +/- 17.5 ng/ml (p = 0.58) before and 30 and 180 days after treatment, respectively.<br />Conclusion: The corneal epithelial barrier function remained intact following the instillation of latanoprost in both groups.<br /> (Copyright 2002 S. Karger AG, Basel)
- Subjects :
- Administration, Topical
Adult
Aged
Aged, 80 and over
Contrast Media pharmacokinetics
Drug Therapy, Combination
Fluorescein pharmacokinetics
Fluorophotometry
Glaucoma physiopathology
Humans
Intraocular Pressure drug effects
Latanoprost
Middle Aged
Permeability drug effects
Prostaglandins F, Synthetic administration & dosage
Epithelium, Corneal drug effects
Epithelium, Corneal metabolism
Glaucoma drug therapy
Glaucoma metabolism
Prostaglandins F, Synthetic therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0030-3755
- Volume :
- 216
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde
- Publication Type :
- Academic Journal
- Accession number :
- 12424402
- Full Text :
- https://doi.org/10.1159/000066180