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Ghrelin expression in islet cell tumors: augmented expression of ghrelin in a case of glucagonoma with multiple endocrine neoplasm type I.
- Source :
-
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2002 Nov; Vol. 87 (11), pp. 4885-8. - Publication Year :
- 2002
-
Abstract
- Ghrelin is a 28-amino acid peptide that regulates GH release together with GHRH and somatostatin. The expression of ghrelin has been detected in the stomach, small intestine, hypothalamus, pituitary gland, kidney, placenta, and testis. Recently it was reported that ghrelin is present in pancreatic alpha-cells and that it stimulates insulin secretion. In this study, we examined the ghrelin expression in two cases of glucagonoma and two cases of insulinoma by Northern blot analysis and immunohistochemistry. Ghrelin expression was identified in a case of glucagonoma associated with multiple endocrine neoplasm type I both by Northern blot analysis using total RNA and by immunohistochemistry, although the plasma ghrelin level was not elevated. This is the first case of tumor in which ghrelin gene expression was detected by Northern blot analysis using total RNA.
- Subjects :
- Adult
Blotting, Northern
Female
Ghrelin
Glucagonoma chemistry
Glucose Tolerance Test
Humans
Immunohistochemistry
Male
Middle Aged
Pancreatic Neoplasms chemistry
Peptide Hormones blood
RNA analysis
Reverse Transcriptase Polymerase Chain Reaction
Adenoma, Islet Cell metabolism
Gene Expression
Glucagonoma metabolism
Multiple Endocrine Neoplasia Type 1 genetics
Pancreatic Neoplasms metabolism
Peptide Hormones genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0021-972X
- Volume :
- 87
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 12414844
- Full Text :
- https://doi.org/10.1210/jc.2002-020882