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DITPA stimulates bFGF, VEGF, angiopoietin, and Tie-2 and facilitates coronary arteriolar growth.
- Source :
-
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2003 Feb; Vol. 284 (2), pp. H613-8. Date of Electronic Publication: 2002 Oct 31. - Publication Year :
- 2003
-
Abstract
- Previous studies from our laboratory and those of others have shown thyroxine to be a stimulator of coronary microvascular growth. The present study tested the hypothesis that 3,5-diiodothyropropionic acid (DITPA), a thyroid hormone analog with inotropic but not chronotopic characteristics, is angiogenic in the nonischemic heart. Daily injections (3.75 mg/kg sc) of DITPA to Sprague-Dawley rats affected protein increases in vascular endothelial growth factor (VEGF)(164), VEGF(188,) basic fibroblast growth factor (bFGF) (FGF-2), angiopoietin-1, and Tie-2 during the first few days of treatment. After 3 wk of treatment, arteriolar length density and the relative number of terminal arterioles (<10 microm diameter) increased in the left ventricle as determined by image analysis of perfuse-fixed hearts. These findings occurred in hearts that did not undergo changes in mass nor in increases in capillary length density. We conclude that DITPA, which is known to improve ventricular function after infarction, is angiogenic in normal nonischemic hearts.
- Subjects :
- Angiopoietin-1
Animals
Arterioles drug effects
Arterioles growth & development
Coronary Vessels drug effects
Male
Rats
Rats, Sprague-Dawley
Receptor, TIE-2
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Angiogenesis Inducing Agents metabolism
Coronary Vessels growth & development
Diiodothyronines pharmacology
Endothelial Growth Factors metabolism
Fibroblast Growth Factor 2 metabolism
Intercellular Signaling Peptides and Proteins metabolism
Lymphokines metabolism
Membrane Glycoproteins metabolism
Neoplasm Proteins metabolism
Propionates pharmacology
Proto-Oncogene Proteins
Subjects
Details
- Language :
- English
- ISSN :
- 0363-6135
- Volume :
- 284
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Heart and circulatory physiology
- Publication Type :
- Academic Journal
- Accession number :
- 12414442
- Full Text :
- https://doi.org/10.1152/ajpheart.00449.2002