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Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2.
- Source :
-
Science (New York, N.Y.) [Science] 2002 Nov 01; Vol. 298 (5595), pp. 1025-9. - Publication Year :
- 2002
-
Abstract
- beta-Defensins are small antimicrobial peptides of the innate immune system produced in response to microbial infection of mucosal tissue and skin. We demonstrate that murine beta-defensin 2 (mDF2beta) acts directly on immature dendritic cells as an endogenous ligand for Toll-like receptor 4 (TLR-4), inducing up-regulation of costimulatory molecules and dendritic cell maturation. These events, in turn, trigger robust, type 1 polarized adaptive immune responses in vivo, suggesting that mDF2beta may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigens.
- Subjects :
- Animals
Antigens, Neoplasm immunology
Cancer Vaccines immunology
Cell Line
Cytokines biosynthesis
Female
Humans
Interferon-alpha physiology
Ligands
Lipopolysaccharides immunology
Lipopolysaccharides pharmacology
Lymphocyte Culture Test, Mixed
Membrane Glycoproteins genetics
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Mice, Inbred C57BL
Neoplasms immunology
Neoplasms therapy
Receptors, CCR6
Receptors, Cell Surface genetics
Receptors, Chemokine metabolism
Recombinant Fusion Proteins pharmacology
Signal Transduction
Toll-Like Receptor 4
Toll-Like Receptors
Transfection
beta-Defensins pharmacology
Dendritic Cells immunology
Drosophila Proteins
Membrane Glycoproteins physiology
Receptors, Cell Surface physiology
beta-Defensins physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 298
- Issue :
- 5595
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 12411706
- Full Text :
- https://doi.org/10.1126/science.1075565