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Comparison of tibolone and conjugated equine estrogens effects on carotid artery atherosclerosis of postmenopausal monkeys.
- Source :
-
Stroke [Stroke] 2002 Nov; Vol. 33 (11), pp. 2700-3. - Publication Year :
- 2002
-
Abstract
- Background and Purpose: Tibolone is a tissue-specific compound that has favorable effects on bone and menopausal symptoms without stimulating endometrium or breast, but lowers concentrations of plasma high-density lipoprotein (HDL) cholesterol (HDLC). This study was designed to determine whether the HDL lowering with tibolone exacerbated common or internal carotid artery atherosclerosis and to evaluate tibolone treatment relative to conjugated equine estrogens (CEE) alone or in combination with medroxyprogesterone acetate (MPA).<br />Methods: Carotid artery atherosclerosis was compared in groups of surgically postmenopausal cynomolgus monkeys treated with CEE, CEE+MPA, or either of 2 doses of tibolone versus untreated monkeys.<br />Results: Despite a 30% to 52% lowering of HDLC with tibolone, there was no significant effect on carotid artery atherosclerosis. CEE and CEE+MPA, however, inhibited carotid artery atherosclerosis by approximately 60%.<br />Conclusions: In surgically postmenopausal cynomolgus monkeys, CEE and CEE+MPA inhibited common and internal carotid artery atherosclerosis. Despite the potentially adverse effects of tibolone on HDLC, tibolone did not exacerbate atherosclerosis.
- Subjects :
- Animals
Carotid Artery Diseases blood
Carotid Artery Diseases pathology
Carotid Artery, Common drug effects
Carotid Artery, Common pathology
Carotid Artery, Internal drug effects
Carotid Artery, Internal pathology
Cholesterol, HDL blood
Cholesterol, HDL drug effects
Cholesterol, VLDL blood
Diet, Atherogenic
Disease Models, Animal
Disease Progression
Drug Therapy, Combination
Estrogen Replacement Therapy
Female
Lipoproteins, LDL blood
Macaca fascicularis
Medroxyprogesterone Acetate therapeutic use
Postmenopause blood
Time
Vascular Patency drug effects
Carotid Artery Diseases prevention & control
Estrogen Receptor Modulators therapeutic use
Estrogens, Conjugated (USP) therapeutic use
Norpregnenes pharmacology
Postmenopause drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4628
- Volume :
- 33
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Stroke
- Publication Type :
- Academic Journal
- Accession number :
- 12411664
- Full Text :
- https://doi.org/10.1161/01.str.0000033130.82164.24