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Pituitary adenylate cyclase-activating polypeptide (PACAP) prevents hippocampal neurons from apoptosis by inhibiting JNK/SAPK and p38 signal transduction pathways.
Pituitary adenylate cyclase-activating polypeptide (PACAP) prevents hippocampal neurons from apoptosis by inhibiting JNK/SAPK and p38 signal transduction pathways.
- Source :
-
Regulatory peptides [Regul Pept] 2002 Nov 15; Vol. 109 (1-3), pp. 83-8. - Publication Year :
- 2002
-
Abstract
- We have demonstrated that ischemic neuronal death (apoptosis) of rat CA1 region of the hippocampus was prevented by infusing pituitary adenylate cyclase-activating polypeptide (PACAP) either intracerebroventricularly or intravenously. We have also demonstrated that the activity of mitogen-activated protein (MAP) kinase family members, including ERK (extracellular signal-regulated kinase), Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) and p38, was increased in the hippocampus within 1-6 h after brain ischemia. The molecular mechanisms underlying the PACAP anti-apoptotic effect were demonstrated in this study. Ischemic stress had a strong influence on MAP kinase family, especially on JNK/SAPK and p38. PACAP inhibited the activation of JNK/SAPK and p38 after ischemic stress, while ERK is not suppressed. These findings suggest that PACAP inhibits the JNK/SAPK and p38 signaling pathways, thereby protecting neurons against apoptosis.
- Subjects :
- Animals
Brain Ischemia enzymology
Brain Ischemia metabolism
Hippocampus enzymology
JNK Mitogen-Activated Protein Kinases
Male
Mitogen-Activated Protein Kinases metabolism
Neuropeptides administration & dosage
Pituitary Adenylate Cyclase-Activating Polypeptide
Rats
Rats, Sprague-Dawley
Time Factors
p38 Mitogen-Activated Protein Kinases
Apoptosis drug effects
Hippocampus drug effects
Hippocampus pathology
Mitogen-Activated Protein Kinases antagonists & inhibitors
Neuropeptides pharmacology
Signal Transduction drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0167-0115
- Volume :
- 109
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- Regulatory peptides
- Publication Type :
- Academic Journal
- Accession number :
- 12409219
- Full Text :
- https://doi.org/10.1016/s0167-0115(02)00190-8