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Pituitary adenylate cyclase-activating polypeptide (PACAP) prevents hippocampal neurons from apoptosis by inhibiting JNK/SAPK and p38 signal transduction pathways.

Pituitary adenylate cyclase-activating polypeptide (PACAP) prevents hippocampal neurons from apoptosis by inhibiting JNK/SAPK and p38 signal transduction pathways.

Authors :
Dohi K
Mizushima H
Nakajo S
Ohtaki H
Matsunaga S
Aruga T
Shioda S
Source :
Regulatory peptides [Regul Pept] 2002 Nov 15; Vol. 109 (1-3), pp. 83-8.
Publication Year :
2002

Abstract

We have demonstrated that ischemic neuronal death (apoptosis) of rat CA1 region of the hippocampus was prevented by infusing pituitary adenylate cyclase-activating polypeptide (PACAP) either intracerebroventricularly or intravenously. We have also demonstrated that the activity of mitogen-activated protein (MAP) kinase family members, including ERK (extracellular signal-regulated kinase), Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) and p38, was increased in the hippocampus within 1-6 h after brain ischemia. The molecular mechanisms underlying the PACAP anti-apoptotic effect were demonstrated in this study. Ischemic stress had a strong influence on MAP kinase family, especially on JNK/SAPK and p38. PACAP inhibited the activation of JNK/SAPK and p38 after ischemic stress, while ERK is not suppressed. These findings suggest that PACAP inhibits the JNK/SAPK and p38 signaling pathways, thereby protecting neurons against apoptosis.

Details

Language :
English
ISSN :
0167-0115
Volume :
109
Issue :
1-3
Database :
MEDLINE
Journal :
Regulatory peptides
Publication Type :
Academic Journal
Accession number :
12409219
Full Text :
https://doi.org/10.1016/s0167-0115(02)00190-8