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Donor CMV serostatus has no impact on CMV viremia or disease when prophylactic granulocyte transfusions are given following allogeneic peripheral blood stem cell transplantation.
- Source :
-
Blood [Blood] 2003 Mar 01; Vol. 101 (5), pp. 2067-9. Date of Electronic Publication: 2002 Oct 24. - Publication Year :
- 2003
-
Abstract
- We studied the impact of donor cytomegalovirus (CMV) serologic status on CMV viremia and disease when prophylactic granulocyte colony-stimulating factor (G-CSF)-mobilized granulocyte transfusions (GTs) were given following allogeneic peripheral blood stem cell (AlloPBSC) transplantation. A cohort of 83 patients who received 2 prophylactic GTs from ABO-compatible stem cell donors following AlloPBSC transplantation was compared with a cohort of 142 patients who did not. AlloPBSC donors were eligible for granulocyte donation irrespective of their CMV serostatus. Recipients received no prophylactic therapy for CMV. Donor CMV serostatus had no impact on CMV viremia and disease in the 2 cohorts. Our data show that in an era of effective surveillance and preemptive therapy for CMV, AlloPBSC recipients can safely receive 2 transfusions of prophylactic G-CSF-mobilized granulocyte components from CMV-seropositive AlloPBSC donors. This knowledge may help expand the donor pool in areas with a high prevalence of CMV in the general population.
- Subjects :
- Adolescent
Adult
Aged
Cohort Studies
Cytomegalovirus physiology
Cytomegalovirus Infections epidemiology
Female
Graft vs Host Disease epidemiology
Graft vs Host Disease etiology
Granulocyte Colony-Stimulating Factor pharmacology
Granulocytes virology
Hematologic Neoplasms therapy
Humans
Incidence
Male
Middle Aged
Neutropenia etiology
Prospective Studies
Random Allocation
Safety
Transplantation Conditioning
Transplantation, Homologous
Viremia epidemiology
Cytomegalovirus Infections transmission
Granulocytes transplantation
Leukocyte Transfusion adverse effects
Neutropenia therapy
Peripheral Blood Stem Cell Transplantation adverse effects
Tissue Donors
Viremia transmission
Subjects
Details
- Language :
- English
- ISSN :
- 0006-4971
- Volume :
- 101
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Blood
- Publication Type :
- Academic Journal
- Accession number :
- 12406871
- Full Text :
- https://doi.org/10.1182/blood-2002-07-2110