Dose escalation, safety and immunogenicity study of a tetravalent meninogococcal polysaccharide diphtheria conjugate vaccine in toddlers.

Authors :: Rennels M
King J Jr
Ryall R
Manoff S
Papa T
Weddle A
Froeschle J
Source :: The Pediatric infectious disease journal [Pediatr Infect Dis J] 2002 Oct; Vol. 21 (10), pp. 978-9.
Publication Year :: 2002
Abstract: Two injections of tetravalent (Groups A, C, Y and W-135) meningococcal polysaccharide vaccine conjugated to diphtheria were given to 30 toddlers at dosages of 1, 4 and 10 microg/ml polysaccharide of each serogroup. Reactogenicity was acceptable at all dosages. The 4-microg/ml dose appears to be immunologically optimal.

Subjects :: Child, Preschool
Dose-Response Relationship, Drug
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunization Schedule
Infant
Male
Polysaccharides, Bacterial
Safety
Sensitivity and Specificity
Treatment Outcome
Vaccines, Conjugate
Antigens, Bacterial analysis
Immunity physiology
Meningococcal Infections prevention & control
Meningococcal Vaccines administration & dosage
Vaccination methods

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