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Structure, function and molecular genetics of human and murine C1r.
- Source :
-
Immunobiology [Immunobiology] 2002 Sep; Vol. 205 (4-5), pp. 365-82. - Publication Year :
- 2002
-
Abstract
- C1r, the enzyme responsible for intrinsic activation of the C1 complex of complement, is a modular serine protease featuring an overall structural organization homologous to those of C1s and the mannan-binding lectin-associated serine proteases (MASPs). This review will initially summarize current information on the structure and function of C1r, with particular emphasis on the three-dimensional structure of its catalytic domain, which provides new insights into the activation mechanism of C1. The second part of this review will focus on recent discoveries dealing with a truncated, C1r-related protein, and the occurrence in the mouse of two isoforms, C1rA and C1rB, exhibiting tissue-specific expression patterns.
Details
- Language :
- English
- ISSN :
- 0171-2985
- Volume :
- 205
- Issue :
- 4-5
- Database :
- MEDLINE
- Journal :
- Immunobiology
- Publication Type :
- Academic Journal
- Accession number :
- 12396000
- Full Text :
- https://doi.org/10.1078/0171-2985-00139