Back to Search
Start Over
Effects of exercise and beta 2-agonists on lung function in chronic obstructive pulmonary disease.
- Source :
-
Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 2002 Dec; Vol. 93 (6), pp. 2053-8. Date of Electronic Publication: 2002 Sep 06. - Publication Year :
- 2002
-
Abstract
- The effects of inhaled bronchodilators at rest and during exercise were studied in 15 subjects with chronic obstructive pulmonary disease. In a crossover study against placebo, albuterol caused a significant increase in expiratory flow and reduced lung hyperinflation and dyspnea at rest, but this was not associated with differences in symptoms with exercise or any relevant parameter of physical performance. Dynamic hyperinflation occurred during exercise similarly after placebo or albuterol and was associated with a reduction of forced expiratory flows. This, in turn, was correlated with the bronchoconstrictor effect of deep inhalation determined at rest. In a parallel group study, expiratory flow was increased by 3-wk treatment with salmeterol (n = 9) but not with placebo (n = 6). However, in neither group was the response to exercise different from baseline. These results suggest that in chronic obstructive pulmonary disease effective pharmacological bronchodilation at rest may not be predictive of benefits of exercise tolerance. This may be related to the occurrence of airway narrowing during exercise, particularly when a deep inhalation at rest is followed by a decrease in expiratory flow.
- Subjects :
- Aged
Bronchoconstriction drug effects
Cross-Over Studies
Dyspnea drug therapy
Dyspnea physiopathology
Forced Expiratory Volume drug effects
Functional Residual Capacity drug effects
Humans
Male
Middle Aged
Pulmonary Disease, Chronic Obstructive physiopathology
Respiratory Mechanics drug effects
Rest
Adrenergic beta-Agonists administration & dosage
Albuterol administration & dosage
Exercise physiology
Pulmonary Disease, Chronic Obstructive drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 8750-7587
- Volume :
- 93
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of applied physiology (Bethesda, Md. : 1985)
- Publication Type :
- Academic Journal
- Accession number :
- 12391117
- Full Text :
- https://doi.org/10.1152/japplphysiol.00490.2002