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Olfactory bulbectomy attenuates cardiovascular sympathoexcitatory reflexes in rats.
- Source :
-
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2002 Dec; Vol. 283 (6), pp. H2575-83. Date of Electronic Publication: 2002 Aug 22. - Publication Year :
- 2002
-
Abstract
- Bilateral removal of the olfactory lobes in rats produces a number of behavioral, endocrine, and neurochemical alterations in the brain. Little is known, however, regarding the effects of this treatment on cardiovascular function and autonomic reflexes. Male Sprague-Dawley rats underwent bilateral surgical ablation of the olfactory bulbs (n = 10) or were sham operated (n = 8). After 3 wk of recovery, animals were instrumented with femoral catheters and a lumbar sympathetic nerve recording electrode. After 24 h of recovery, cardiovascular responses to arterial baroreflex manipulation, air jet stress, and smoke exposure were recorded. Olfactory bulbectomized rats demonstrated attenuated sympathoexcitatory responses to hypotension, air jet stress, and smoke exposure, as well as elevated basal blood pressure, compared with sham-operated rats. These data indicate that the integrity of the olfactory bulbs in rats is important for the elicitation of normal cardiovascular and autonomic responses to a number of evocative stimuli.
- Subjects :
- Animals
Baroreflex physiology
Blood Pressure drug effects
Blood Pressure physiology
Catheterization
Electrodes, Implanted
Ganglionic Blockers pharmacology
Heart Rate physiology
Lumbosacral Region
Male
Neurosurgical Procedures
Olfactory Bulb surgery
Rats
Rats, Sprague-Dawley
Smoke adverse effects
Stress, Physiological
Synaptic Transmission physiology
Cardiovascular System innervation
Olfactory Bulb physiology
Reflex, Abnormal physiology
Sympathetic Nervous System physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0363-6135
- Volume :
- 283
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Heart and circulatory physiology
- Publication Type :
- Academic Journal
- Accession number :
- 12388291
- Full Text :
- https://doi.org/10.1152/ajpheart.00164.2002