Clinical strain of Pseudomonas aeruginosa carrying a bla(TEM-21) gene located on a chromosomal interrupted TnA type transposon.

Authors :: Dubois V
Arpin C
Noury P
Quentin C
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2002 Nov; Vol. 46 (11), pp. 3624-6.
Publication Year :: 2002
Abstract: A clinical isolate of Pseudomonas aeruginosa was found to produce a clavulanic acid-inhibited extended-spectrum beta-lactamase with a pI of 6.4. PCR, cloning, and sequencing experiments showed that the corresponding bla(TEM-21) gene was part of a chromosomally located Tn801 transposon disrupted by an IS6100 element and adjacent to an aac(3)-II gene.

Subjects :: Aged
Antibiotics, Antitubercular pharmacology
Azides pharmacology
Chromosomes, Bacterial drug effects
Conjugation, Genetic
DNA, Bacterial genetics
Drug Resistance, Bacterial
Escherichia coli drug effects
Escherichia coli genetics
Female
Humans
Molecular Sequence Data
Reverse Transcriptase Polymerase Chain Reaction
Rifampin pharmacology
Chromosomes, Bacterial genetics
Pseudomonas Infections microbiology
Pseudomonas aeruginosa drug effects
Pseudomonas aeruginosa genetics
beta-Lactamases genetics

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