The kinetics of the removal of the N-methyltrityl (Mtt) group during the synthesis of branched peptides.

Authors :: Li D
Elbert DL
Source :: The journal of peptide research : official journal of the American Peptide Society [J Pept Res] 2002 Nov; Vol. 60 (5), pp. 300-3.
Publication Year :: 2002
Abstract: The purpose of this short communication is to describe the reaction rate for the removal of the N-methyltrityl (Mtt) protecting group that is used in solid-phase peptide synthesis for the production of branched and cyclic peptides. The reaction rate was observed to follow zero-order kinetics, and we suggest the optimal conditions for the removal of the Mtt group in batchwise synthesis.

Subjects :: Kinetics
Mass Spectrometry
Peptides chemistry
Spectrophotometry
Peptides chemical synthesis
Trityl Compounds chemistry

Language :: English
ISSN :: 1397-002X
Volume :: 60
Issue :: 5
Database :: MEDLINE
Journal :: The journal of peptide research : official journal of the American Peptide Society
Publication Type :: Academic Journal
Accession number :: 12383120
Full Text :: https://doi.org/10.1034/j.1399-3011.2002.21018.x

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