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Replacing the no-effect level (NOEL) with bounded effect levels (OBEL and LEBEL).
- Source :
-
Statistics in medicine [Stat Med] 2002 Oct 30; Vol. 21 (20), pp. 3071-8. - Publication Year :
- 2002
-
Abstract
- From experiments or epidemiological studies designed to search for a particular toxic effect, it is in general possible to determine an upper bound for that effect. This observed bounded effect level (OBEL) is defined for both positive and negative experiments. It is non-zero even for negative experiments, and it is inversely related to the size of the exposed group. The OBEL can be used to determine the linearly extrapolated bounded effect level (LEBEL) for various effect doses. Contrary to no-observed-effect' levels (NOELs), LEBEL values are designed to protect against type II (false negative) errors. It is proposed that LEBEL values replace NOELs as a tool for decision-making.<br /> (Copyright 2002 John Wiley & Sons, Ltd.)
- Subjects :
- Animals
Confidence Intervals
Fatty Liver chemically induced
Humans
Inhalation Exposure adverse effects
Mesothelioma chemically induced
Occupational Exposure adverse effects
Respiratory Tract Neoplasms chemically induced
Solvents toxicity
Data Interpretation, Statistical
No-Observed-Adverse-Effect Level
Toxicity Tests methods
Subjects
Details
- Language :
- English
- ISSN :
- 0277-6715
- Volume :
- 21
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Statistics in medicine
- Publication Type :
- Academic Journal
- Accession number :
- 12369082
- Full Text :
- https://doi.org/10.1002/sim.1220