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Plasma and tissue iron changes in the rat after acute administration of ethionine.
- Source :
-
Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 1975 Nov-Dec; Vol. 2 (6), pp. 459-67. - Publication Year :
- 1975
-
Abstract
- 1. Ethionine administered acutely to the adult female rat markedly elevates and then lowers plasma iron concentration over several days. Liver iron undergoes a reverse cycle. 2. Ethionine does not cause changes in the blood parameters, including total plasma iron-binding capacity and plasma iron clearance. Erythrocytes of rats injected with ethionine show altered responses to hypertonicity. 3. Increased reticulo-endothelial activity of the spleen, indicated by increased uptake of 59Fe-labelled erythrocytes by liver and spleen, apparently contributes to plasma iron elevation. Also the liver releases iron which further raises plasma iron.
- Subjects :
- Animals
Erythrocytes drug effects
Erythrocytes metabolism
Ethionine antagonists & inhibitors
Female
Iron blood
Liver drug effects
Liver metabolism
Osmotic Fragility drug effects
Rats
Spleen drug effects
Spleen metabolism
Time Factors
Transferrin metabolism
Ethionine pharmacology
Iron metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0305-1870
- Volume :
- 2
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Clinical and experimental pharmacology & physiology
- Publication Type :
- Academic Journal
- Accession number :
- 1236600
- Full Text :
- https://doi.org/10.1111/j.1440-1681.1975.tb01851.x