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Polymorphisms of the cytomegalovirus (CMV)-encoded tumor necrosis factor-alpha and beta-chemokine receptors in congenital CMV disease.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2002 Oct 15; Vol. 186 (8), pp. 1057-64. Date of Electronic Publication: 2002 Sep 30. - Publication Year :
- 2002
-
Abstract
- Some congenital cytomegalovirus (CMV) infections lead to neonatal disease, whereas others have no associated sequelae. To explore a possible role for viral genes as determinants of virulence, portions of the UL144 tumor necrosis factor (TNF)-alpha-like receptor gene, the US28 beta-chemokine receptor gene, and the UL55 envelope glycoprotein B gene from 33 patients with congenital CMV infection were sequenced. Three major UL144 subtypes (A, B, and C) and 2 recombinants (A/C and A/B) were detected. Infection with the least common UL144 subtypes (A, C, A/C, and A/B) was associated with unfavorable disease outcome (P=.04). There was no association between specific subtypes of the US28 and UL55 genes and outcome (P=.864 and P=.765, respectively). Multiple genotypes (implying multiple infections) were detected in tissues from 8 of 10 autopsies. Therefore, polymorphism in the CMV-encoded TNF-alpha-like receptor appears to be associated with congenital CMV disease. Other CMV polymorphisms should be further evaluated for potential relevance to neonatal infection, transplantation, and acquired immunodeficiency syndrome-associated CMV diseases.
- Subjects :
- Amino Acid Sequence
Cytomegalovirus pathogenicity
Cytomegalovirus Infections mortality
Cytomegalovirus Infections transmission
Female
Genes, Viral genetics
Genotype
Humans
Infant, Newborn
Infant, Newborn, Diseases mortality
Infectious Disease Transmission, Vertical
Membrane Glycoproteins chemistry
Membrane Glycoproteins genetics
Molecular Sequence Data
Phylogeny
Polymerase Chain Reaction
Pregnancy
Receptors, Chemokine chemistry
Receptors, Tumor Necrosis Factor chemistry
Viral Proteins chemistry
Viral Proteins genetics
Virulence
Cytomegalovirus genetics
Cytomegalovirus Infections congenital
Cytomegalovirus Infections virology
Infant, Newborn, Diseases virology
Polymorphism, Genetic genetics
Receptors, Chemokine genetics
Receptors, Tumor Necrosis Factor genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 186
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 12355354
- Full Text :
- https://doi.org/10.1086/344238