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A method to compare four mouthrinses: time to gingivitis level as the primary outcome variable.
- Source :
-
Journal of clinical periodontology [J Clin Periodontol] 2002 Jun; Vol. 29 (6), pp. 519-23. - Publication Year :
- 2002
-
Abstract
- Background and Aim: The experimental gingivitis model is a well-established method in comparing the chemical antiplaque activity of agents and products. The aim of the present study was to use time in order to achieve an exit level of bleeding on probing (BOP) as the primary outcome variable.<br />Methods: The study was a single blind, randomised four treatment parallel group design employing 76 healthy volunteers. The cohort was accepted into the study proper if they achieved a level of </= 25% BOP after a 5-week pre-study oral hygiene phase. At baseline, 1, 2, 3, 4, 5 weeks BOP, modified gingival index (MGI) and plaque index scores were obtained from each subject. After baseline, oral hygiene was suspended and subjects rinsed twice daily with one of the test rinses, namely: 1 0.05% cetylpyridinium chloride 2 Control fluoride 3 0.2% chlorhexidine 4 0.3% triclosan Subjects were removed from the study when they achieved >/= 50% BOP. Using the baseline and exit BOP, MGI and plaque, a deterioration rate for each parameter was derived and used as the unit of analysis.<br />Results: There were highly significant treatment differences for all three parameters. Paired analyses revealed chlorhexidine was highly significantly more effective than the other rinses for all three parameters. CPC and triclosan were not different from the control for BOP, but CPC was significantly different from the control for MGI and plaque, and triclosan was different from the control for plaque. There were no differences between the CPC and triclosan rinses.<br />Conclusions: The method achieved the expected result of differentiating between the chlorhexidine and the other rinses. Some modification of the method, primarily to group sizes, should improve specificity. The method has the considerable volunteer appeal of early exit, particularly when allocated to control or low activity treatments for plaque.
- Subjects :
- Adult
Analysis of Variance
Anti-Infective Agents, Local administration & dosage
Anti-Infective Agents, Local therapeutic use
Cariostatic Agents administration & dosage
Cariostatic Agents therapeutic use
Cetylpyridinium administration & dosage
Cetylpyridinium therapeutic use
Chlorhexidine administration & dosage
Chlorhexidine therapeutic use
Cohort Studies
Dental Plaque Index
Female
Fluorides administration & dosage
Fluorides therapeutic use
Gingival Hemorrhage prevention & control
Humans
Male
Matched-Pair Analysis
Oral Hygiene
Periodontal Index
Sensitivity and Specificity
Single-Blind Method
Statistics as Topic
Time Factors
Treatment Outcome
Triclosan administration & dosage
Triclosan therapeutic use
Dental Plaque prevention & control
Gingivitis prevention & control
Mouthwashes therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0303-6979
- Volume :
- 29
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of clinical periodontology
- Publication Type :
- Academic Journal
- Accession number :
- 12296779
- Full Text :
- https://doi.org/10.1034/j.1600-051x.2002.290608.x