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Neuroprotection against ischemic brain injury conferred by a novel nitrate ester.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2002 Oct 21; Vol. 12 (20), pp. 2863-6. - Publication Year :
- 2002
-
Abstract
- Nitrates exhibit a selectivity of action in different tissue types not fully recognized: in particular, the neuromodulatory and cardiovascular properties can be dissociated. A novel nitrate showed relatively weak systemic effects, but in the middle cerebral artery occlusion rat model of focal ischemia, reduced the cerebral infarct by 60-70% when administered 4 h after the onset of ischemia.
- Subjects :
- Animals
Blood Pressure drug effects
Brain pathology
Brain Ischemia pathology
Cyclic GMP physiology
Dose-Response Relationship, Drug
Guanylate Cyclase metabolism
In Vitro Techniques
Infarction, Middle Cerebral Artery drug therapy
Infarction, Middle Cerebral Artery pathology
Muscle Relaxation
Muscle, Smooth, Vascular drug effects
Nitroglycerin pharmacology
Propane pharmacology
Rats
Vasodilator Agents pharmacology
Brain Ischemia drug therapy
Neuroprotective Agents chemical synthesis
Neuroprotective Agents pharmacology
Nitrates chemical synthesis
Nitrates pharmacology
Propane analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 12
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 12270164
- Full Text :
- https://doi.org/10.1016/s0960-894x(02)00631-5