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Desensitization and subsequent kidney transplantation of patients using intravenous immunoglobulins (IVIg).

Authors :
Glotz D
Antoine C
Julia P
Suberbielle-Boissel C
Boudjeltia S
Fraoui R
Hacen C
Duboust A
Bariety J
Source :
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2002 Sep; Vol. 2 (8), pp. 758-60.
Publication Year :
2002

Abstract

Transplantation of patients possessing antibodies against allo-HLA antigens can be delayed for years. We have shown that administration of intravenous immunoglobulins (IVIg) can induce a profound and sustained decrease in the titers of anti-HLA antibodies. We report here the first series of patients desensitized, then transplanted using IVIg therapy. Fifteen patients have been included and treated with IVIg, given as 3 monthly courses of 2g/kg body weight. Thirteen of those 15 patients (87%) were effectively desensitized and underwent immediate transplantation. Eleven were transplanted with a cadaveric donor, and two with a living donor against which the pretreatment cross-match was positive. One graft was lost from thrombosis and one from rejection. All other patients had uneventful courses, without any episodes of rejection, with a follow-up of more than 1 year. Thus, IVIg therapy allows safe and prompt kidney transplantation of immunized patients.

Details

Language :
English
ISSN :
1600-6135
Volume :
2
Issue :
8
Database :
MEDLINE
Journal :
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Publication Type :
Academic Journal
Accession number :
12243496
Full Text :
https://doi.org/10.1034/j.1600-6143.2002.20809.x