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Protein Engineering of Insulin: [B9 Glutamic Acid] Human Insulin.
- Source :
-
Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica [Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai)] 1996; Vol. 28 (3), pp. 245-249. - Publication Year :
- 1996
-
Abstract
- B9Ser of insulin B chain was substituted by Glu using site-directed mutagenesis to obtain a fast-acting insulin-[B9Glu] human insulin. The receptor binding capacity and in vivo biological activity of [B9Glu] human insulin are 21% and 40% as those of porcine insulin respectively.
Details
- Language :
- English
- ISSN :
- 0582-9879
- Volume :
- 28
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica
- Publication Type :
- Academic Journal
- Accession number :
- 12237678