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Role of X-linked inhibitor of apoptosis protein in chemoresistance in ovarian cancer: possible involvement of the phosphoinositide-3 kinase/Akt pathway.
- Source :
-
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy [Drug Resist Updat] 2002 Jul-Aug; Vol. 5 (3-4), pp. 131-46. - Publication Year :
- 2002
-
Abstract
- Although cisplatin derivatives are first-line chemotherapeutic agents for the treatment of epithelial ovarian cancer, chemoresistance remains a major hurdle to successful therapy and the molecular mechanisms involved are poorly understood. Apoptosis is the cellular underpinning of cisplatin-induced cell death, which is associated with expression of specific "death" genes and down-regulation of "survival" counterparts. The X-linked inhibitor of apoptosis proteins (Xiap), an intracellular anti-apoptotic protein, plays a key role in cell survival by modulating death signaling pathways and is a determinant of cisplatin resistance in ovarian cancer cells in vitro. This review focuses on the role of Xiap and its interactions with the phosphoinositide-3 kinase (PI3K)/Akt cell survival pathway in conferring resistance of ovarian cancer cells to chemotherapeutic agents and discusses potential therapeutic strategies in overcoming chemoresistant ovarian cancer.
- Subjects :
- Apoptosis physiology
Female
Humans
Proteins physiology
Proto-Oncogene Proteins c-akt
X-Linked Inhibitor of Apoptosis Protein
Apoptosis drug effects
Cisplatin therapeutic use
Drug Resistance, Neoplasm physiology
Ovarian Neoplasms drug therapy
Phosphatidylinositol 3-Kinases physiology
Protein Serine-Threonine Kinases
Proteins therapeutic use
Proto-Oncogene Proteins physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1368-7646
- Volume :
- 5
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 12237081
- Full Text :
- https://doi.org/10.1016/s1368-7646(02)00003-1