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Serial evaluation of high-resolution computed tomography findings in patients with idiopathic pulmonary fibrosis in usual interstitial pneumonia.
- Source :
-
Respiration; international review of thoracic diseases [Respiration] 2002; Vol. 69 (5), pp. 413-9. - Publication Year :
- 2002
-
Abstract
- Background: The development of well-matured fibrosis in usual interstitial pneumonia (UIP) is strongly associated with an unfavorable outcome of patients with idiopathic pulmonary fibrosis (IPF). However, differences in the rates of development are likely to result in variable clinical courses in IPF patients.<br />Objective: We tried to evaluate the progression of honeycombing and ground-glass opacity on CT using a scoring system, and to examine those serial changes in the clinical course of disease.<br />Methods: A hospital-based, retrospective cohort study. Twenty-three patients with IPF diagnosed as UIP by surgical lung biopsy were analyzed during the initial examination by scoring the presence of honeycombing (HC: range, 0-24) and ground-glass opacity (GG: range, 0-24) on CT scan. We also compared the serial changes observed in the CT scores (interval: 2-42 months, 2-6 examinations).<br />Results: (1) The serial change in the HC score in treated patients (n = 10) was similar to that in untreated patients (n = 16); (2) the HC score at the time of the initial examination and the rate of HC progression were both higher in the non-surviving patients (HC 12.3 +/- 3.7, mean +/- SD; deltaHC 4.2 +/- 1.3 per year) than in the surviving patients (HC 5.8 +/- 2.7; deltaHC 1.2 +/- 0.7 per year) (p < 0.05); (3) the GG score did not correlate with the HC score at any of the examinations; (4) the HC score was higher in the lower lung field than in the upper and middle lung fields.<br />Conclusions: Scoring of the honeycombing and its serial changes using the high-resolution computed tomography scoring method was useful for predicting the prognosis in patients with IPF/UIP. Corticosteroid treatment did not prevent the progression of HC.<br /> (Copyright 2002 S. Karger AG, Basel)
- Subjects :
- Adult
Aged
Anti-Inflammatory Agents therapeutic use
Cohort Studies
Disease Progression
Female
Humans
Lung Diseases, Interstitial drug therapy
Lung Diseases, Interstitial pathology
Male
Middle Aged
Prednisone therapeutic use
Prognosis
Pulmonary Fibrosis drug therapy
Pulmonary Fibrosis pathology
Retrospective Studies
Sensitivity and Specificity
Survival Rate
Lung Diseases, Interstitial complications
Lung Diseases, Interstitial diagnostic imaging
Pulmonary Fibrosis complications
Pulmonary Fibrosis diagnostic imaging
Radiographic Image Enhancement methods
Tomography, X-Ray Computed methods
Subjects
Details
- Language :
- English
- ISSN :
- 0025-7931
- Volume :
- 69
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Respiration; international review of thoracic diseases
- Publication Type :
- Academic Journal
- Accession number :
- 12232448
- Full Text :
- https://doi.org/10.1159/000064006