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Cell interactions with three-dimensional matrices.
- Source :
-
Current opinion in cell biology [Curr Opin Cell Biol] 2002 Oct; Vol. 14 (5), pp. 633-9. - Publication Year :
- 2002
-
Abstract
- Signaling and other cellular functions differ in three-dimensional compared with two-dimensional systems. Cell adhesion structures can evolve in vitro towards in-vivo-like adhesions with distinct biological activities. In this review, we examine recent advances in studies of interactions of fibroblasts with collagen gels and fibronectin-containing matrices that mimic in vivo three-dimensional microenvironments. These three-dimensional systems are illuminating mechanisms of cell-matrix interactions in living organisms.
Details
- Language :
- English
- ISSN :
- 0955-0674
- Volume :
- 14
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Current opinion in cell biology
- Publication Type :
- Academic Journal
- Accession number :
- 12231360
- Full Text :
- https://doi.org/10.1016/s0955-0674(02)00364-2