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[Effects of ethanol on the pulmonary artery endothelium in rats].

Authors :
Marchenko SM
Source :
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) [Fiziol Zh (1994)] 2002; Vol. 48 (4), pp. 39-42.
Publication Year :
2002

Abstract

Effects of ethanol on membrane potential and intracellular calcium concentration in intact endothelium of isolated pulmonary arteries were investigated. Ethanol evoked hyperpolarization and biphasic increase in [Ca2+]i in the endothelium due to both Ca2+ release from intracellular stores and Ca2+ entry from extracellular solution. These data allow endothelium-dependent dilation of pulmonary artery evoked by ethanol to be explained.

Subjects

Subjects :
Animals
Endothelium, Vascular drug effects
In Vitro Techniques
Male
Membrane Potentials drug effects
Membrane Potentials physiology
Pulmonary Artery drug effects
Rats
Calcium metabolism
Endothelium, Vascular physiology
Ethanol pharmacology
Pulmonary Artery physiology

Details

Language :
Ukrainian
ISSN :
2522-9028
Volume :
48
Issue :
4
Database :
MEDLINE
Journal :
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)
Publication Type :
Academic Journal
Accession number :
12226924

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