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Bacteraemia due to Stenotrophomonas maltophilia: an analysis of 45 episodes.
- Source :
-
The Journal of infection [J Infect] 2002 Jul; Vol. 45 (1), pp. 47-53. - Publication Year :
- 2002
-
Abstract
- Objective: Stenotrophomonas maltophilia is an important nosocomial pathogen and a therapeutic challenge. A ten-year review of episodes of bacteraemia due to S. maltophilia was undertaken in light of reports of an increasing frequency of infection.<br />Methods: A retrospective analysis of bloodstream infections due toS. maltophilia at a tertiary care hospital in Melbourne, Australia. Cases were identified via microbiology laboratory reports, and relevant clinical data were collected from the medical record of each patient.<br />Results: Eighty per cent of these 45 episodes were nosocomial. The most common characteristics in cases of bacteraemia were the presence of an indwelling central venous catheter (CVC) (38/45, 84%) and previous antibiotic therapy (33/45, 73%). There were 8 deaths (8/44, 18%) within 7 days of bacteraemia. A significant correlation was found between deaths and a failure to remove the CVC (P = 0.01) or treat with appropriate antimicrobials (P = 0.01). Antibiotic susceptibility testing revealed that isolates were most sensitive to sulphamethoxazole (80%), chloramphenicol (75.5%) and ceftazidime (64.5%).<br />Conclusions: S. maltophilia is an important pathogen especially in the highly compromised host. Isolation of this organism from a blood culture should prompt a careful review of the patient with particular emphasis on removal of indwelling CVCs and commencement of appropriate antibiotic therapy.<br /> (Copyright 2002 The British Infection Society)
- Subjects :
- Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents pharmacology
Australia
Bacteremia mortality
Catheterization, Central Venous adverse effects
Cross Infection microbiology
Cross Infection mortality
Drug Resistance, Bacterial
Female
Gram-Negative Bacterial Infections mortality
Humans
Male
Middle Aged
Odds Ratio
Opportunistic Infections microbiology
Opportunistic Infections mortality
Retrospective Studies
Risk Factors
Stenotrophomonas maltophilia drug effects
Treatment Outcome
Bacteremia epidemiology
Bacteremia microbiology
Gram-Negative Bacterial Infections epidemiology
Gram-Negative Bacterial Infections microbiology
Stenotrophomonas maltophilia isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 0163-4453
- Volume :
- 45
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of infection
- Publication Type :
- Academic Journal
- Accession number :
- 12217732
- Full Text :
- https://doi.org/10.1053/jinf.2002.0978