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Coeliac disease: dissecting a complex inflammatory disorder.
- Source :
-
Nature reviews. Immunology [Nat Rev Immunol] 2002 Sep; Vol. 2 (9), pp. 647-55. - Publication Year :
- 2002
-
Abstract
- The disease mechanisms of complex inflammatory disorders are difficult to define because of extensive interactions between genetic and environmental factors. Coeliac disease is a typical complex inflammatory disorder, but this disease is unusual in that crucial genetic and environmental factors have been identified. This knowledge has allowed functional studies of the predisposing HLA molecules, the identification of antigenic epitopes and detailed studies of disease-relevant T cells in coeliac disease. This dissection of the pathogenic mechanisms of coeliac disease has uncovered principles that are relevant to other chronic inflammatory diseases.
- Subjects :
- Amino Acid Sequence
Autoimmune Diseases immunology
CD4-Positive T-Lymphocytes immunology
Celiac Disease genetics
Celiac Disease pathology
Epitopes chemistry
Epitopes immunology
GTP-Binding Proteins analysis
Genetic Predisposition to Disease
Glutens immunology
Glutens metabolism
HLA-DQ Antigens genetics
Humans
Interferon-gamma analysis
Intestinal Mucosa immunology
Intestinal Mucosa pathology
Intestine, Small enzymology
Intestine, Small immunology
Intestine, Small pathology
Molecular Sequence Data
Protein Glutamine gamma Glutamyltransferase 2
Transglutaminases analysis
Celiac Disease immunology
HLA-DQ Antigens immunology
Inflammation immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1474-1733
- Volume :
- 2
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Nature reviews. Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 12209133
- Full Text :
- https://doi.org/10.1038/nri885