Back to Search
Start Over
Antigen degradation or presentation by MHC class I molecules via classical and non-classical pathways.
- Source :
-
Molecular immunology [Mol Immunol] 2002 Oct; Vol. 39 (3-4), pp. 181-202. - Publication Year :
- 2002
-
Abstract
- Major histocompatibility complex (MHC) class I molecules usually present endogenous peptides at the cell surface. This is the result of a cascade of events involving various dedicated proteins like the peptide transporter associated with antigen processing (TAP) and the ER chaperone tapasin. However, alternative ways for class I peptide loading exist which may be highly relevant in a process called cross-priming. Both pathways are described here in detail. One major difference between these pathways is that the proteases involved in the generation of peptides are different. How proteases and peptidases influence peptide generation and degradation will be discussed. These processes determine the amount of peptides available for TAP translocation and class I binding and ultimately the immune response.
- Subjects :
- ATP Binding Cassette Transporter, Subfamily B, Member 2
ATP Binding Cassette Transporter, Subfamily B, Member 3
ATP-Binding Cassette Transporters physiology
Animals
Cysteine Endopeptidases physiology
Cytosol metabolism
Golgi Apparatus metabolism
Histocompatibility Antigens Class I chemistry
Humans
Multienzyme Complexes physiology
Phagosomes metabolism
Proteasome Endopeptidase Complex
Substrate Specificity
Antigen Presentation
Antigens metabolism
Histocompatibility Antigens Class I metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0161-5890
- Volume :
- 39
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Molecular immunology
- Publication Type :
- Academic Journal
- Accession number :
- 12200050
- Full Text :
- https://doi.org/10.1016/s0161-5890(02)00101-3