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Anti-inhibitor coagulant complex for the rescue therapy of acquired inhibitors to factor VIII: case report and review of the literature.
- Source :
-
Haemophilia : the official journal of the World Federation of Hemophilia [Haemophilia] 2002 Sep; Vol. 8 (5), pp. 694-7. - Publication Year :
- 2002
-
Abstract
- A 62-year-old African-American man with a history of hypertension, asthma, and prostate cancer, but no prior history of haemophilia presented with gross haematuria following a motor vehicle accident. Coagulation studies revealed a prolonged partial thromboplastin time. Subsequent mixing study and factor analysis confirmed factor VIII (FVIII) deficiency. The patient subsequently developed a knee haemarthrosis associated with persistent haematuria and a profoundly elevated FVIII inhibitor titre. Fresh frozen plasma was initiated upon presentation. Once FVIII inhibitor was discovered, immunosuppressive agents were started. Concurrent treatment with acute bypass agents including porcine FVIII, and recombinant human factor VIIa (rFVIIa;NovoSeven), was also given. Ultimately, anti-inhibitor coagulant complex (Autoplex T) was administered, stabilizing the haematuria and haemarthrosis. There was no additional bleeding 6 months after the last dose of anti-inhibitor coagulant complex. This case is consistent with others in which anti-inhibitor coagulant complex therapy was used successfully to manage patients with serious acute bleeding problems who are found to have acquired inhibitors to factor VIII.
- Subjects :
- Accidents, Traffic
Acute Disease
Factor VIII administration & dosage
Factor VIII immunology
Hematuria immunology
Hemophilia A immunology
Humans
Immunosuppressive Agents therapeutic use
Male
Middle Aged
Prednisone therapeutic use
Recombinant Proteins administration & dosage
Autoantibodies immunology
Blood Coagulation Factor Inhibitors blood
Blood Coagulation Factors therapeutic use
Factor VIII antagonists & inhibitors
Hematuria drug therapy
Hemophilia A drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1351-8216
- Volume :
- 8
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Haemophilia : the official journal of the World Federation of Hemophilia
- Publication Type :
- Academic Journal
- Accession number :
- 12199681
- Full Text :
- https://doi.org/10.1046/j.1365-2516.2002.00652.x